PSO Based Deployment of Hybrid Sensor Networks

With the rapid increase in the usage of wireless sensor networks, it is emerging as a technology for monitoring various physical activities. The essential characteristics of wireless sensor network are coverage, cost, connectivity and lifetime which are dependent upon the number and type of sensors being used for the required task. A random deployment strategy of sensor nodes may cause coverage holes in the sensing ?eld. The work presented here shall mainly focus on deployment strategy of WSNs which will improve the coverage area that poses the biggest challenge to the developers. Most of the problems related to WSNs are modelled and approached as multi objective functions through various genetic algorithms. PSO is one such technique that is e?cient and computationally e?cient in addressing various issues such as optimising sensor deployment and localization of sensor nodes. A modi?ed particle swarm optimization (PSO) technique using grid based strategy has been proposed for sensor deployment which is capable of e?ciently deploying the sensors with an objective of maximizing the coverage ratio. It will determine the optimum location of the mobile nodes after the initial random deployment .The optimality rate of this approach is also higher as compared to other genetic algorithms

ANTIHYPERGLYCEMIC ACTIVITY OF PHENYL AND ORTHO-HYDROXY PHENYL LINKED IMIDAZOLYL TRIAZOLO HYDROXAMIC ACID DERIVATIVES

Objective: The paradigm was to establish phenyl and ortho-hydroxy phenyl linked imidazolyl triazolo hydroxamic acid derivatives as an antihyperglycemic agent.Methods: 100 mg/Kg body weight dose of phenyl and ortho-hydroxy Phenyl linked Imidazolyl triazolo Hydroxamic Acid derivatives (FP1-FP12) and standard glibenclamide were administered per os (p.o.) in the streptozotocin-induced hyperglycemic rats by glucose oxidase-peroxidase method and statistically evaluated by one way analysis of variance.Results: FP3 was potent as compare to standard glibenclamide (P < 0.05-0.001) and FP6, FP9, and FP4 were also effective as an antihyperglycemic agent. The activity profile of the molecule was as follows FP9< FP10< FP4< FP6<FP12< FP3. This study reflects that presence of para methoxy phenyl group linked with phenyl group in surface recognition portion and imidazolyl triazole group in linker portion associated with a sulfamethyl hydroxamic acid group in metal identifying the part in case of FP3 was resemble for antihyperglycemic activity.Conclusion: It was concluded that compounds possessing electron releasing groups on the aromatic rings in the surface recognition part considerably enhanced the antihyperglycemic activity

Design, synthesis and antiproliferative activity of hydroxyacetamide derivatives against HeLa cervical carcinoma cell and breast cancer cell line

Purpose: To design and develop a new series of histone deacetylase inhibitors (FP1 - FP12) and evaluate their inhibitory activity against hydroxyacetamide (HDAC) enzyme mixture-derived HeLa cervical carcinoma cell and MCF-7.Methods: The designed molecules (FP1 - FP12) were docked using AUTODOCK 1.4.6. FP3 and FP8 showed higher interaction comparable to the prototypical HDACI. The designed series of 2-[[(3- Phenyl/substituted Phenyl-[4-{(4- (substituted phenyl)ethylidine-2-Phenyl-1,3-Imidazol-5-One}](-4H- 1,2,4-triazol-5-yl)sulfanyl]-N-hydroxyacetamide derivatives (FP1-FP12) was synthesized by merging 2- [(4-amino-3-phenyl-4H- 1, 2, 4-triazol-5-yl) sulfanyl]- N-hydroxyacetamide and 2-{[4-amino-3-(2- hydroxyphenyl)-4H-1,2, 4-triazol-5-yl]sulfanyl}-N hydroxyacetamide derivatives with aromatic substitutedoxazolone. The biological activity of the synthesized molecule (FP1-FP12) was evaluated against HDAC enzyme mixture-derived HeLa cervical carcinoma cell and breast cancer cell line (MCF-7).Results: HDAC inhibitory activity of FP10 showed higher IC50 (half-maximal  concentration inhibitory activity) of 0.09 μM, whereas standard SAHA molecule showed IC50 of 0.057 μM. On the other hand, FP9 exhibited higher GI50 (50 % of maximal concentration that inhibited cell proliferation) of 22.8 μM against MCF-7 cell line, compared with the standard, adriamycin, with GI50 of (-) 50.2 μM.Conclusion: Synthesis, spectral characterization, and evaluation of HDAC inhibition activity and in vitro anticancer evaluation of novel hydroxyacetamide derivatives against MCF-7 cell line have been achieved. The findings indicate the emergence of potentialanticancer compounds.Keywords: Molecular docking, Hydroxyacetamide derivative, Histone deacetylase inhibition activity, MCF-7 cell lin

CONCEPT OF GENETICS IN AYURVED

Ayurved is accepted as an oldest written medical system and it came into existence at least three thousand years before Christ. Though the present understanding of human genetics owes much to the work of Gregor Mendel but the first scientific theme on genetics had been emphasized in ancient Indian literatures. Although the technical term Genetics does not feature in Ayurved but the theme of genetics is vibrant repeatedly all classical text of Ayurved especially in Samhitas. It is an outstanding contribution of Ayurved on genetics is being described on the following heads i.e., concept of basic unit of genetics like Beeja - Beejabhag - Beejabhgavayab, concept of mutation, inheriting factors, concept of fertilization and sex determination, description of congenital diseases like Madhumeha, Arsha, Kustha etc. Prakriti and its clinical applications, therapy applied for Pumsavan kriya, how to prevent birth of a physically and mentally handicapped child. The review focuses on the various literary concept and clinical applications of genetics in Ayurved. The literary portion and clinical part of the work was done during post graduate study to established the Genetic concept in Ayurved in concordance with modern phenomena and to know the prevalence of chromosomal anomalies both autosomal and sex chromosome in patients presenting with congenital malformation. The work has been published as dissertation of post graduate study

Anti-inflammatory and analgesic activities of imidazolyl triazolo hydroxamic acid derivatives

280-285Hydroxamic acids are directly related with cancer and its progression. Long term exposure with inflammatory responses, dysplasia develops which leads to cancer. Metastasis of cancer and expression of transient potential receptor ankyrin-1 are known to cause severe pain. Here, we explored the possibility of developing newer hydroxamic acid derivatives as anti-inflammatory and analgesic agent. Animals were administered with 100 mg/kg dose of the synthesized imidazolyl triazolo hydroxamic acid derivatives (FP1-FP12) and 50 mg/kg dose of standard diclofenac sodium. Carrageenan induced rat paw edema and Eddy’s hot plate methods were considered for anti-inflammatory and analgesic activities. Among all the synthesized molecules, FP10 and FP4 were the most effective anti-inflammatory and analgesic agent, respectively. The activity profile of remaining molecules as anti-inflammatory agents was as follows: FP4>FP9> FP8> FP2 and as analgesic activity profile was FP10>FP3>FP8 >FP11 >FP2 > FP12. Presence of ethyl- benzyl and furan groups in linker portion of the structure minimized both the anti-inflammatory and analgesic activities. Results have shown that compounds with electron releasing groups considerably enhance both anti-inflammatory and analgesic activities

Use of Phased Array Ultrasonic Testing For Sizing of Hydrogen Blisters In LPG Wash Water Vessel In INDMAX Unit

Equipments operating in sour environment containing H2S are prone to deterioration by wet H2S damage mechanism. INDMAX unit (patented FCCU) produces LPG which contains H2S, cyanide as impurities. To remove these impurities LPG is treated with caustic wash and subsequently water wash in series operation. Due to presence of wet H2S environment in the water wash vessel, nascent hydrogen is produced which diffuses in to the wall of the vessel. Due to presence of laminations in the CS shell these hydrogen atoms combined to form hydrogen molecule which exerts severe internal pressure greater than the yield strength of the CS wall inside the laminations resulting in formation of hydrogen blister. This paper describes the use of phased array UT (PAUT) technique for detection of lamination and sizing of hydrogen blisters in the LPG wash water vessel. Fitness for purpose study was carried out for safe operation of this vessel

Do innovative immersive virtual reality simulation videos have a role to play in teaching non-technical skills and increasing preparedness for clinical placements for medical students?

This article was migrated. The article was not marked as recommended. Teaching non-technical skills (NTS) is an important part of the undergraduate medical curriculum. Resource intensive high-fidelity simulation has an established role in this. We developed an innovative series of immersive virtual reality simulation videos for medical students. We found they demonstrated efficacy in teaching NTS and after viewing students felt better prepared for clinical placements.</ns4:p

Inhibition of PHLPP1/2 phosphatases rescues pancreatic β-cells in diabetes

Pancreatic β-cell failure is the key pathogenic element of the complex metabolic deterioration in type 2 diabetes (T2D); its underlying pathomechanism is still elusive. Here, we identify pleckstrin homology domain leucine-rich repeat protein phosphatases 1 and 2 (PHLPP1/2) as phosphatases whose upregulation leads to β-cell failure in diabetes. PHLPP levels are highly elevated in metabolically stressed human and rodent diabetic β-cells. Sustained hyper-activation of mechanistic target of rapamycin complex 1 (mTORC1) is the primary mechanism of the PHLPP upregulation linking chronic metabolic stress to ultimate β-cell death. PHLPPs directly dephosphorylate and regulate activities of β-cell survival-dependent kinases AKT and MST1, constituting a regulatory triangle loop to control β-cell apoptosis. Genetic inhibition of PHLPPs markedly improves β-cell survival and function in experimental models of diabetes in vitro, in vivo, and in primary human T2D islets. Our study presents PHLPPs as targets for functional regenerative therapy of pancreatic β cells in diabetes

Catalytic applications of waste derived materials

Sustainability has become a watchword and guiding principle for modern society, and with it a growing appreciation that anthropogenic 'waste', in all its manifold forms, can offer a valuable source of energy, construction materials, chemicals and high value functional products. In the context of chemical transformations, waste materials not only provide alternative renewable feedstocks, but also a resource from which to create catalysts. Such waste-derived heterogeneous catalysts serve to improve the overall energy and atom-efficiency of existing and novel chemical processes. This review outlines key chemical transformations for which waste-derived heterogeneous catalysts have been developed, spanning biomass conversion to environmental remediation, and their benefits and disadvantages relative to conventional catalytic technologies